Based on the DC character Superman’s cousin, Kara Zor-El (series star MELISSA BENOIST), after 12 years of keeping her powers a secret on Earth, decides to finally embrace her superhuman abilities and be the hero she was always meant to be. Twelve-year-old Kara escaped the doomed planet Krypton with her parents’ help at the same time as the infant Kal-El. Protected and raised on Earth by her foster parents, Jeremiah and Eliza Danvers (guest stars DEAN CAIN and HELEN SLATER), Kara grew up in the shadow of her foster sister, Alex (series star CHYLER LEIGH), and learned to conceal the phenomenal powers she shares with her famous cousin in order to keep her identity a secret.
Years later, Kara was living in National City and still concealing her powers, when a plane crash threatened Alex’s life and Kara took to the sky to save her. Now, Kara balances her work as a reporter for CatCo Worldwide Media with her work for the Department of Extra-Normal Operations (DEO), a super-secret government organization whose mission is to keep National City – and the Earth – safe from sinister threats. At the DEO, Kara works for J’onn J’onzz (series star DAVID HAREWOOD), the Martian Manhunter, and alongside her sister, Alex, and best friend, Winn Schott (series star JEREMY JORDAN). Also in Kara’s life are media mogul Cat Grant (recurring guest star CALISTA FLOCKHART), James Olsen (series star MEHCAD BROOKS), a photojournalist who moonlights as Guardian, a masked vigilante, Lena Luthor (new series regular KATIE McGRATH), and Mon-El of Daxam (series star CHRIS WOOD), whose planet was ravaged by Krypton’s destruction. As Kara struggles to navigate her relationships and her burgeoning life as a reporter, her heart soars as she takes to the skies as Supergirl to fight crime.